enzyme activity – Communicable Diseases Research

Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease

Article

Published on 2022-09-012022-11-16
Journal: Cells
[Category] 유전자 메커니즘,

Structural basis for inhibition and regulation of a chitin synthase from Candida albicans

Research

Published on 2022-07-042022-10-05
Journal: Nature Structural & Molecular Biology
[Category] 변종,

[키워드] binding Candida albican chitin conserved Control cryo-EM structure enzyme activity Extracellular fungal cell wall inhibitor mechanism membrane motif non-specific Prevent Regulation Synthase target translocation unique
[DOI] 10.1038/s41594-022-00791-x [Article Type] Research

Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients

순환하는 디 펩 티딜 펩 티다 제 -4 효소 활성 감소는 Covid-19 입원 환자의 심각한 결과에 대한 예후이다.

Observational Study

Published on 2022-04-012022-08-31
Journal: Biomarkers in Medicine
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상,

[키워드] activity age characteristic circulating circulating DPP4 activity Combination Control COVID-19 COVID-19 disease death Decreased Dipeptidyl peptidase-4 disease disease severity Donor DPP4 enzyme activity group hospitalized COVID-19 patient hospitalized patient hospitalized patients indicated Inpatient Logistic regression material median Mortality outcome patients with COVID-19 plasma prognostic prognostic biomarker prognostic biomarker. Prognostic marker receiver operating characteristic sampling SARS-CoV-2 serum serum sample serum samples severe COVID-19 disease severity significant decrease study group study groups T2DM were assessed were used WHO with COVID-19
[DOI] 10.2217/bmm-2021-0717 PMC 바로가기 [Article Type] Observational Study

Instant determination of the artemisinin from various Artemisia annua L. extracts by LC-ESI-MS/MS and their in-silico modelling and in vitro antiviral activity studies against SARS-CoV-2

LC-ESI-MS/MS 및 SARS-CoV-2에 대한 in-silico 모델링 및 시험관 내 항바이러스 활성 연구에 의한 다양한 Artemisia annua L. 추출물의 artemisinin의 즉각적인 측정

Article

Published on 2022-03-012022-09-11
Journal: Phytochemical analysis : PCA
[Category] SARS, 치료제,

[키워드] 3CL 50% effective concentration additional treatment option Antiviral antiviral activity applied Artemisia annua SARS-CoV-2 Artemisinin binding biological activity can be used Cell cell viability COVID-19 COVID-19 treatment determine Direct dose effort energy transfer enzyme activity greater HEK293T cell line immunosuppressive effect immunosuppressive effects in silico in vitro in-silico LC-ESI-MS/MS lipopolysaccharide Liquid chromatography mass spectrometry Medicines molecular natural products for COVID-19. Numerous patients plant Prophylactic protease Protease activity pseudovirus reported resolved SARS-CoV-2 SARS-CoV-2 virus spike Spike protein Tandem mass spectrometry THP-1 TNF-α Treatment Turkey viability
[DOI] 10.1002/pca.3088 PMC 바로가기 [Article Type] Article

Efficacy of liriope platyphylla extract for improving respiratory functions Study protocol for a randomized, double-blinded, placebo-controlled pilot trial

호흡기 기능 향상을위한 Liriope Platyphylla 추출물의 효능 무작위, 이중 맹검, 위약 대조 파일럿 시험을위한 연구 프로토콜의 효능

3700

Published on 2022-02-112022-08-31
Journal: Medicine
[Category] COVID19(2023년), MERS, SARS, 임상, 치료제,

[키워드] liriope platyphylla accompany allergic inflammation anti-inflammatory effect Anti-inflammatory effects anti-inflammatory properties antioxidant assumption Asthma breathlessness bronchitis changes in chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) clinical symptom Clinical symptoms clinical trial conducted COPD COPD Assessment Test score cough COVID-19 determine disease dose double-blind double-blinded Dyspnea Effect Efficacy and safety ENhance enzyme activity exclusion criteria first randomized controlled trial Follow-up Frequency frequency of occurrence functional health help immune cells immune factor immune factors Immunity IMPROVE include Inclusion Intervention mechanism nitric oxide obstructive pulmonary disease Occurrence outcome participant Placebo placebo-controlled Previous studies previous study Primary outcome proceed protocol pulmonary disease Pulmonary function questionnaire Randomized Randomized controlled trial Randomly RATs receive reported respiratory Respiratory disease Respiratory function respiratory inflammation secondary Secondary outcomes single-center sputum Symptom Trial
[DOI] 10.1097/MD.0000000000028452 PMC 바로가기 [Article Type] 3700

Development and Validation of a Novel HPLC Method to Analyse Metabolic Reaction Products Catalysed by the CYP3A2 Isoform: In Vitro Inhibition of CYP3A2 Enzyme Activity by Aspirin (Drugs Often Used Together in COVID-19 Treatment)

Article

Published on 2022-01-292022-10-30
Journal: Molecules
[Category] Coronavirus, SARS,

Pro108Ser mutation of SARS-CoV-2 3CL pro reduces the enzyme activity and ameliorates the clinical severity of COVID-19

SARS-COV-2 3CL PRO의 PRO108SER 돌연변이는 효소 활성을 감소시키고 COVID-19의 임상 적 심각성을 개선시킨다.

Article

Published on 2022-01-252022-09-10
Journal: Scientific Reports
[Category] 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] 3CL pro Amino acid amino acid residue characterization chymotrypsin Clinical course Clinical severity clinical trial Controlled clinical trial COVID-19 COVID-19 in patient death demonstrated deuterium enzymatic activity enzyme enzyme activity Enzyme mechanisms hospital hydrogen infected with SARS-CoV-2 Infection inhibitor International Lineage lower risk mass spectrometry mutant Mutation oxygen oxygen supplementation Patient patients with SARS-CoV-2 PF-07321332 Placebo positioned proportion protease Randomized reduce reduced required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains strain Support symptom onset the patient treated Trial viral infection virus
[DOI] 10.1038/s41598-022-05424-3 PMC 바로가기 [Article Type] Article

Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets

Article

Published on 2022-01-122022-10-28
Journal: Pharmaceutics
[Category] COVID-19,

[키워드] 3C-like protease (3CL^pro/M^pro) 3CL pro accelerate acute respiratory syndrome addition anti-SARS-CoV-2 antiviral potency approved assays bioinformatics Compound coronavirus coronavirus disease COVID-19 docking simulation domain drug Drug screening enzyme activity evaluated feasible food identification infections inhibitory inhibitory effect Multiple other diseases Papain-like protease papain-like protease (PL^pro) protease RBD reduction repurposing SARS-CoV-2 serine 2 severe acute respiratory syndrome coronavirus 2 Tamoxifen target therapeutic potential these compound TMPRSS2 transmembrane transmembrane protease serine 2 (TMPRSS2) Treatment Vaccines
[DOI] 10.3390/pharmaceutics14010176 PMC 바로가기 [Article Type] Article

Bilirubin levels as an independent predictor of myocarditis in patients with COVID-19

Research

Published on 2021-12-202022-10-31
Journal: The Egyptian Heart Journal
[Category] COVID-19,

Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients

심혈관 환자에서 SARS-CoV-2 세포 수용체 ACE2 수준의 변화: COVID-19 환자 계층화를 위한 잠재적 바이오마커

Original Article

Published on 2021-10-212022-09-11
Journal: GeroScience
[Category] MERS, SARS, 바이오마커,

[키워드] ACE2 ACE2 expression ACEi activities activity affected angiotensin Angiotensin converting enzyme 2 (ACE2) Angiotensin-converting enzyme angiotensin-converting enzyme 2 Biomarker blood pressure cardiovascular disease cardiovascular diseases cardiovascular status cellular entry cellular receptor change circulating Comorbidity Compliance controls COVID-19 COVID-19 patient Effect Ejection fraction elevated ELISA enzyme enzyme activity healthy individuals heart failure Heart transplantation human serum hypertension hypertensive hypertensive patients individual inhibitory left left ventricle left ventricular ejection fraction lung lung cancer lung tissue male Male sex medication medications Mortality negative correlation no correlation obese Older overweight Pathomechanism Pathomechanisms Patient patients RAAS inhibitors RAS renin-angiotensin-aldosterone system (RAAS) SARS-CoV-2 serum severe COVID-19 severity Sex Stratification subject the SARS-CoV-2 Thoracic Thoracic Surgery tissue Treatment Ventricle ventricular ventricular ejection was increased without affecting
[DOI] 10.1007/s11357-021-00467-2 PMC 바로가기 [Article Type] Original Article